Nile University (NU) stands as one of Egypt’s pioneering institutions in institutionalizing innovation and entrepreneurship as a strategic pillar of its mission. Through a unique, practice-based approach, NU has built a comprehensive ecosystem that nurtures entrepreneurs, supports research commercialization, and connects students, faculty, startups, and industry under one collaborative umbrella. The university established the Innovation, Entrepreneurship, and Competitiveness Center (IECC) to lead acceleration programs, university-industry collaborations, and R&D as a service. Over 450 startup teams and 800 SMEs have received direct support, more than 200 products developed, while more than 25,000 individuals have been trained. NU is also home to one of the country’s most impactful national initiatives—NilePreneurs—which bridges academia and the economy through innovation hubs, SME development, and policy engagement. Curricularly, NU introduced forward-thinking courses such as Blue Economy Entrepreneurship and Entrepreneurship for Wastewater Reuse, where students work on real-world challenges in climate-sensitive and underserved regions. Looking forward, NU is launching the Nile Innovation Park, a hub for deep tech and applied research ventures. It is restructuring its innovation pillar into three strategic units—IECC, EDGE (Ecosystem Development & Growth Engine), and IDEA-LAB (Innovation Development & Entrepreneurship Assessment Lab)—to expand impact across research, policy, and education. What remains is scaling this impact, deepening integration with national strategic priorities (e.g., green hydrogen, water security), and ensuring long-term sustainability of the innovation support team and infrastructure.