The Centre for Advanced Learning Technologies in Science, Technology, Engineering, Arts, and Mathematics (CALTSTEAM) stands as a trailblazing hub for innovation, inclusivity, and societal impact in STEAM education. Situated at the University of Johannesburg, CALTSTEAM directly addresses the pressing challenges of youth unemployment and educational inequality in South Africa and across the Global South. The Centre pioneers the integration of advanced learning technologies such as artificial intelligence (AI), virtual reality (VR), and augmented reality (AR) into school and university education, with a distinct focus on making these technologies accessible to young people from disadvantaged and marginalized communities. Unique in its approach, CALTSTEAM fuses cultural relevance with cutting-edge digital innovation, transforming science learning into an immersive, engaging, and culturally meaningful experience. At the heart of CALTSTEAM’s mission is a commitment to youth empowerment through digital skills development. Initiatives such as the XR Online Coding Club equip learners with practical, in-demand skills in XR design, coding, and application development. This proactive skills transfer creates pathways for young people to transition from passive consumers to active creators of technology, with the potential to launch their own entrepreneurial ventures and technology start-ups. The Centre views digital innovation not merely as an educational tool but as a driver for youth employment, entrepreneurship, and economic inclusion. CALTSTEAM’s holistic approach integrates teacher development, learner empowerment, and community engagement through initiatives like CAVARS and AI-powered learning pathways. By nurturing digital creativity and fostering an entrepreneurial mindset, CALTSTEAM offers scalable, sustainable models for building equitable and future-ready learning ecosystems in Africa—preparing young people not only to participate in but also to shape the digital economy.